rRNA transcription

Across TCGA patient cohorts, RNA activity of the rRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, NCAPH, and DEPDC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transcription activity versus TTK in PDAC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TTK →	+0.810	+0.400	<.001	<.001	2	8
GBM	NCAPH →	+0.602	+0.205	.004	.002	3	7
GBM	DEPDC1 →	+0.867	+0.304	<.001	<.001	3	7
PDAC	GTSE1 →	+0.607	+0.392	<.001	<.001	3	7
GBM	CDC45 →	+0.937	+0.305	<.001	<.001	3	7
BRCA	TICRR →	+0.793	+0.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009303 vs TTK — PDAC

Explore this scatter interactively →