rRNA transcription

Across TCGA cell cohorts, RNA activity of the rRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT1, CCDC92, and INSIG2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transcription activity versus TRMT1 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TRMT1 →	+1.112	+0.318	<.001	.007	3	7
CNS	CCDC92 →	-1.113	-0.262	.003	.005	3	6
LUNG_SCLC	INSIG2 →	-0.589	-0.213	.001	<.001	3	6
LUNG_SCLC	EIF2AK3 →	-0.808	-0.230	<.001	<.001	3	6
LIVER	DYNC2H1 →	+1.892	+0.300	.007	.002	3	6
PANCREAS	TCOF1 →	+1.368	+0.409	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009303 vs TRMT1 — PANCREAS

Explore this scatter interactively →