snRNA transcription

Across TCGA patient cohorts, RNA activity of the snRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB1A, YME1L1, and BRD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription activity versus RAB1A in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAB1A →	-0.175	-0.035	.001	.001	3	6
BRCA	YME1L1 →	-0.253	-0.029	<.001	<.001	3	5
BRCA	BRD3 →	+0.305	+0.035	<.001	.002	3	5
COAD	C4A →	+0.572	+0.027	.006	.001	3	5
PDAC	FUBP3 →	+0.118	+0.045	.001	<.001	3	5
GBM	MAGT1 →	-0.257	-0.034	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009301 vs RAB1A — LSCC

Explore this scatter interactively →