snRNA transcription

Across TCGA cell cohorts, RNA activity of the snRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA1, EVL, and PRODH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription activity versus HMGA1 in BREAST (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HMGA1 →	+2.263	+0.893	.006	<.001	3	7
BREAST	EVL →	-1.698	-0.758	.002	<.001	3	4
LARGE_INTESTINE	PRODH →	-1.720	-0.849	.001	.002	2	4
LARGE_INTESTINE	ACAA2 →	-1.335	-0.666	.004	.004	3	3
LARGE_INTESTINE	CD163L1 →	+1.765	+0.779	.009	.009	3	3
LUNG_NSCLC_LUAD	FERMT3 →	+0.995	+1.220	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009301 vs HMGA1 — BREAST

Explore this scatter interactively →