mRNA transcription

Across TCGA patient cohorts, RNA activity of the mRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOE, PECAM1, and C1S, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA transcription activity versus APOE in COAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	APOE →	+0.505	+0.027	<.001	.003	3	6
OV	PECAM1 →	+0.358	+0.054	.002	<.001	3	6
OV	C1S →	+0.456	+0.053	.003	<.001	3	5
COAD	DOCK11 →	+0.269	+0.029	<.001	.002	3	5
COAD	HOOK2 →	-0.179	-0.030	.005	.003	3	5
LSCC	ICAM1 →	+0.531	+0.036	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009299 vs APOE — COAD

Explore this scatter interactively →