mRNA transcription

Across TCGA patient cohorts, RNA activity of the mRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS1, COL11A1, and TGFB1I1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA transcription activity versus RBMS1 in CCRCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RBMS1 →	+0.289	+0.874	.002	.003	3	5
PDAC	COL11A1 →	+0.724	+0.758	.005	<.001	3	5
CCRCC	TGFB1I1 →	+0.516	+0.826	.002	.004	3	4
PDAC	RCN3 →	+0.455	+0.791	<.001	.001	3	4
OV	CCN1 →	+1.241	+0.922	.007	.001	3	4
CCRCC	SERPINH1 →	+0.459	+1.003	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009299 vs RBMS1 — CCRCC

Explore this scatter interactively →