Response to pH

Across TCGA patient cohorts, RNA activity of the Response to pH pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC2L, ESF1, and EIF5B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to pH activity versus NOC2L in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NOC2L →	-0.326	-0.052	<.001	<.001	3	7
COAD	ESF1 →	-0.418	-0.030	<.001	<.001	3	7
LSCC	EIF5B →	-0.183	-0.052	<.001	<.001	3	7
LSCC	UTP25 →	-0.333	-0.052	<.001	<.001	3	6
LSCC	GTF3C4 →	-0.366	-0.060	<.001	<.001	3	6
LSCC	MPHOSPH10 →	-0.373	-0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009268 vs NOC2L — LSCC

Explore this scatter interactively →