Cellular response to starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to starvation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC3, FURIN, and CYFIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to starvation activity versus RAC3 in BREAST (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAC3 →	-1.015	-0.151	<.001	<.001	3	5
URINARY_TRACT	FURIN →	+1.080	+0.142	.002	.001	3	5
LIVER	CYFIP2 →	-2.558	-0.191	.003	<.001	3	4
STOMACH	TMEM64 →	-1.581	-0.220	.005	.007	3	4
OESOPHAGUS	TOLLIP →	+1.217	+0.159	<.001	<.001	3	4
SOFT_TISSUE	ATP5IF1 →	+0.613	+0.133	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009267 vs RAC3 — BREAST

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