Response to temperature stimulus

Across TCGA patient cohorts, RNA activity of the Response to temperature stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EML6-AS1, CIDEA, and C6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to temperature stimulus activity versus EML6-AS1 in LUAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EML6-AS1 →	-0.808	-0.182	.002	<.001	3	3
BRCA	CIDEA →	+1.196	+0.139	.001	<.001	3	3
BRCA	C6 →	+0.603	+0.128	.004	<.001	3	3
LSCC	SRP9 →	-1.420	-0.224	.003	<.001	3	3
LSCC	NRG4 →	-0.854	-0.224	.007	<.001	3	3
LSCC	BCL3 →	+0.767	+0.224	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009266 vs EML6-AS1 — LUAD

Explore this scatter interactively →