Response to temperature stimulus

Across TCGA cell cohorts, RNA activity of the Response to temperature stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf27, COMMD8, and NTHL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to temperature stimulus activity versus C20orf27 in OVARY (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C20orf27 →	+0.928	+0.203	.006	<.001	3	4
BLOOD_Leukemia	COMMD8 →	-1.004	-0.142	<.001	<.001	3	4
BLOOD_Leukemia	NTHL1 →	+0.668	+0.101	.009	.009	3	4
LUNG_NSCLC_LUSC	UST →	-1.777	-0.244	.004	<.001	3	4
SOFT_TISSUE	NUDT17 →	-0.856	-0.145	.001	.003	3	3
LUNG_NSCLC_LUAD	PIMREG →	+0.767	+0.158	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009266 vs C20orf27 — OVARY

Explore this scatter interactively →