Deoxyribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleotide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF5, PLEKHO2_S390, and PYCARD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide catabolic process activity versus RNF5 in UCEC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNF5 →	-0.471	-0.082	<.001	.001	3	5
UCEC	PLEKHO2_S390 →	+0.456	+0.093	<.001	<.001	3	5
UCEC	PYCARD →	+0.489	+0.091	<.001	<.001	3	5
OV	DPYD →	+0.451	+0.037	<.001	<.001	3	5
COAD	ZC3H13 →	-0.207	-0.027	<.001	.001	3	4
COAD	PML →	+0.258	+0.023	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009264 vs RNF5 — UCEC

Explore this scatter interactively →