Deoxyribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAICS_S27, PCNA, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide biosynthetic process activity versus PAICS_S27 in LUAD (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAICS_S27 →	+1.583	+0.089	<.001	<.001	3	10
OV	PCNA →	+0.621	+0.067	.001	<.001	3	10
PDAC	RPL12_S38 →	+0.983	+0.068	<.001	<.001	3	10
LSCC	RFC2 →	+0.317	+0.060	<.001	<.001	3	9
UCEC	RRM2 →	+0.887	+0.094	<.001	<.001	3	9
OV	SMC2 →	+0.628	+0.076	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009263 vs PAICS_S27 — LUAD

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