Deoxyribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, PTTG1, and GEN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide biosynthetic process activity versus CENPI in UCEC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPI →	+1.106	+0.335	<.001	<.001	3	8
UCEC	PTTG1 →	+1.234	+0.292	<.001	<.001	3	8
UCEC	GEN1 →	+0.665	+0.292	<.001	<.001	3	8
UCEC	ERCC6L →	+0.777	+0.250	<.001	<.001	3	8
UCEC	FAM72B →	+0.897	+0.332	<.001	<.001	3	8
LUAD	BIRC5 →	+0.898	+0.177	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009263 vs CENPI — UCEC

Explore this scatter interactively →