Deoxyribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCSER2, TMEM263, and MYL12A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide biosynthetic process activity versus CCSER2 in LUNG_SCLC (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCSER2 →	-1.813	-2.145	.006	<.001	3	3
LUNG_SCLC	TMEM263 →	-1.263	-2.156	.001	<.001	3	3
LUNG_SCLC	MYL12A →	-1.323	-2.057	.001	.001	3	2
BREAST	TMEM38B →	+0.569	+2.209	.003	.001	3	2
LUNG_SCLC	POLD2 →	+0.806	+1.855	.004	<.001	3	2
LUNG_SCLC	RNF167 →	-1.136	-2.289	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009263 vs CCSER2 — LUNG_SCLC

Explore this scatter interactively →