Deoxyribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, MCM3, and SPC24, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide metabolic process activity versus RRM2 in LUAD (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRM2 →	+0.645	+0.033	<.001	<.001	3	7
HNSC	MCM3 →	+0.570	+0.084	<.001	<.001	3	7
LSCC	SPC24 →	+0.504	+0.057	<.001	<.001	3	6
OV	MCM5 →	+0.551	+0.030	.004	.006	2	7
HNSC	AURKB →	+0.713	+0.102	<.001	<.001	3	6
LUAD	KIF23 →	+0.583	+0.027	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009262 vs RRM2 — LUAD

Explore this scatter interactively →