Deoxyribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL9, SLAMF8, and C1QA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide metabolic process activity versus CXCL9 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CXCL9 →	+1.718	+0.204	.001	<.001	3	7
CCRCC	SLAMF8 →	+0.890	+0.127	<.001	.001	3	7
CCRCC	C1QA →	+0.441	+0.104	.004	.004	3	7
CCRCC	CCR8 →	+0.796	+0.162	<.001	<.001	3	7
HNSC	IL4I1 →	+1.000	+0.148	<.001	<.001	3	7
HNSC	IRF1 →	+0.795	+0.122	<.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009262 vs CXCL9 — BRCA

Explore this scatter interactively →