Deoxyribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QRICH1, POLA2, and CDIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleotide metabolic process activity versus QRICH1 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	QRICH1 →	+0.482	+0.989	.003	<.001	2	6
LIVER	POLA2 →	+1.075	+2.251	.004	<.001	3	5
URINARY_TRACT	CDIP1 →	+3.000	+2.171	<.001	<.001	3	5
SOFT_TISSUE	NADK →	+1.290	+1.755	.006	.008	3	5
BLOOD_Leukemia	HMGB2 →	+0.694	+0.938	.003	.002	3	5
BLOOD_Leukemia	KLHL25 →	+0.935	+0.858	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009262 vs QRICH1 — BLOOD_Leukemia

Explore this scatter interactively →