Ribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL3, EIF3E, and EIF3M, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleotide catabolic process activity versus RPL3 in CCRCC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL3 →	-0.162	-0.034	.007	<.001	3	5
OV	EIF3E →	-0.212	-0.038	<.001	<.001	3	5
OV	EIF3M →	-0.200	-0.030	<.001	<.001	3	5
GBM	GSPT1 →	-0.172	-0.039	<.001	.001	3	5
BRCA	GUCY1A1 →	+0.474	+0.031	<.001	<.001	3	5
OV	XPO1 →	-0.308	-0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009261 vs RPL3 — CCRCC

Explore this scatter interactively →