Ribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB3BP, S100A8, and DYSF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleotide catabolic process activity versus ITGB3BP in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGB3BP →	-0.629	-0.164	<.001	.001	3	6
COAD	S100A8 →	+1.130	+0.210	.001	.001	3	6
LSCC	DYSF →	+0.549	+0.172	<.001	<.001	3	5
COAD	TNFRSF10C →	+0.701	+0.162	<.001	.009	3	5
LSCC	RAD51AP1 →	-0.654	-0.158	.001	<.001	3	5
UCEC	FPR2 →	+0.855	+0.164	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009261 vs ITGB3BP — LSCC

Explore this scatter interactively →