Ribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPRIP, GPR34, and EBNA1BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITPRIP grouped by Ribonucleotide catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITPRIP →	+1.157	+0.289	.003	.007	3	5
CNS	GPR34 →	-0.053	-0.351	.009	.007	3	5
STOMACH	EBNA1BP2 →	+0.930	+0.155	.006	.006	3	5
LIVER	POR →	-0.944	-0.269	.003	.001	3	5
LUNG_NSCLC_LUAD	SLC13A4 →	-0.301	-0.368	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PLA2G6 →	-1.477	-0.382	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITPRIP by Ribonucleotide catabolic process activity — BREAST

Explore this box plot interactively →