Ribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HINT1, TXNRD1, and TSPAN6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleotide catabolic process activity versus HINT1 in OESOPHAGUS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HINT1 →	+0.930	+0.261	.003	.003	3	8
OVARY	TXNRD1 →	+0.901	+0.297	.004	.004	3	7
STOMACH	TSPAN6 →	-1.654	-0.238	.003	.002	3	6
URINARY_TRACT	POLK →	+0.895	+0.640	.006	.007	3	6
LUNG_SCLC	SAP30 →	+0.938	+0.221	.002	<.001	3	6
OVARY	MAFF →	+1.278	+0.300	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009261 vs HINT1 — OESOPHAGUS

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