Ribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPI1, GPI, and ALDOC, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleotide catabolic process activity versus TPI1 in URINARY_TRACT (Pearson r = 0.91).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TPI1 →	+4.690	+0.759	<.001	<.001	3	17
LARGE_INTESTINE	GPI →	+2.648	+0.367	<.001	<.001	3	16
STOMACH	ALDOC →	+2.222	+0.284	<.001	<.001	3	16
URINARY_TRACT	MIF →	+2.236	+0.470	.001	.001	3	16
URINARY_TRACT	ENO1 →	+3.983	+0.777	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	TBCB →	+1.765	+0.365	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009261 vs TPI1 — URINARY_TRACT

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