10-formyltetrahydrofolate metabolic process

Across TCGA patient cohorts, RNA activity of the 10-formyltetrahydrofolate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1L2, GARS1, and DDX21_S121, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 10-formyltetrahydrofolate metabolic process activity versus ALDH1L2 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALDH1L2 →	+0.543	+0.058	.001	<.001	3	5
BRCA	GARS1 →	+0.332	+0.052	.001	.001	3	4
OV	DDX21_S121 →	+0.710	+0.051	.002	.002	3	4
UCEC	ASNS →	+0.507	+0.088	<.001	<.001	3	4
UCEC	MTHFD1L →	+0.401	+0.074	<.001	.001	3	4
LUAD	ERICH3_S1124 →	-0.906	-0.056	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009256 vs ALDH1L2 — LSCC

Explore this scatter interactively →