10-formyltetrahydrofolate metabolic process

Across TCGA patient cohorts, RNA activity of the 10-formyltetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L1, ALDH1L2, and ALDH1L1-AS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 10-formyltetrahydrofolate metabolic process activity versus ALDH1L1 in PDAC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ALDH1L1 →	+1.133	+0.170	<.001	<.001	3	7
OV	ALDH1L2 →	+0.977	+0.209	.002	.001	2	7
LSCC	ALDH1L1-AS2 →	+0.230	+0.231	.002	<.001	3	5
HNSC	POU2AF1 →	+0.949	+0.172	.001	.003	3	5
BRCA	ARHGAP9 →	+0.668	+0.210	<.001	<.001	3	5
HNSC	STAP1 →	+0.645	+0.146	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009256 vs ALDH1L1 — PDAC

Explore this scatter interactively →