10-formyltetrahydrofolate metabolic process

Across TCGA cell cohorts, RNA activity of the 10-formyltetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXRA7, TBC1D2B, and PHF10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MXRA7 grouped by 10-formyltetrahydrofolate metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MXRA7 →	-1.759	-1.451	.002	<.001	3	4
BREAST	TBC1D2B →	-0.729	-1.067	.004	<.001	3	4
SKIN	PHF10 →	-0.791	-0.893	.007	.008	3	3
SKIN	ARF3 →	+0.374	+0.946	<.001	<.001	3	3
URINARY_TRACT	SQOR →	-3.510	-2.111	.002	<.001	3	3
BLOOD_Myeloma	DMD →	-1.678	-1.539	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MXRA7 by 10-formyltetrahydrofolate metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →