10-formyltetrahydrofolate metabolic process

Across TCGA cell cohorts, RNA activity of the 10-formyltetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF4, TAF4B, and H2AC19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 10-formyltetrahydrofolate metabolic process activity versus NDUFAF4 in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NDUFAF4 →	+0.478	+0.218	.002	.004	3	5
LUNG_SCLC	TAF4B →	+1.152	+0.212	.001	.005	3	5
LUNG_NSCLC_LUSC	H2AC19 →	-1.527	-0.255	<.001	<.001	3	5
BLOOD_Leukemia	NEDD1 →	+0.848	+0.139	<.001	.007	3	5
BLOOD_Myeloma	NUAK1 →	-3.416	-0.463	<.001	.001	3	5
BLOOD_Lymphoma	B4GALT1 →	-1.216	-0.206	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009256 vs NDUFAF4 — LUNG_NSCLC_LUAD

Explore this scatter interactively →