Glucan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glucan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENPP1, COMP, and IRS1_S374, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan biosynthetic process activity versus ENPP1 in LSCC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENPP1 →	+0.773	+0.040	<.001	<.001	3	6
BRCA	COMP →	+0.699	+0.033	.001	<.001	3	6
BRCA	IRS1_S374 →	+0.915	+0.073	.001	<.001	3	5
BRCA	RPL5 →	-0.182	-0.037	<.001	<.001	3	5
HNSC	SAMSN1 →	-0.356	-0.041	.003	.003	3	5
LSCC	SH3BP1 →	-0.261	-0.035	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009250 vs ENPP1 — LSCC

Explore this scatter interactively →