Glucan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glucan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, MSRB3, and ACSS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan biosynthetic process activity versus CNN1 in UCEC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNN1 →	+2.255	+0.362	<.001	.001	3	7
UCEC	MSRB3 →	+1.302	+0.275	<.001	.002	3	7
BRCA	ACSS3 →	+0.713	+0.418	.007	.008	2	7
UCEC	MYH11 →	+1.540	+0.270	<.001	.003	3	6
BRCA	LRRC32 →	+0.783	+0.419	.003	.008	3	6
PDAC	TAGLN →	+0.684	+0.424	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009250 vs CNN1 — UCEC

Explore this scatter interactively →