Glucan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glucan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, GAS6, and SMTN_S245, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan biosynthetic process activity versus VCL in UCEC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VCL →	+0.548	+0.274	<.001	.002	3	5
GBM	GAS6 →	+0.446	+0.286	<.001	.006	3	5
UCEC	SMTN_S245 →	+0.647	+0.219	.001	.001	3	4
COAD	SORBS1_S465 →	+0.785	+0.526	.001	.001	2	5
PDAC	SYNPO_S854 →	+0.517	+0.397	<.001	<.001	3	4
OV	TGFB1I1_S143 →	+1.482	+0.459	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009250 vs VCL — UCEC

Explore this scatter interactively →