Protein lipoylation

Across TCGA patient cohorts, RNA activity of the Protein lipoylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HA2, PPP1R18_S224, and ECM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein lipoylation activity versus P4HA2 in OV (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	P4HA2 →	-0.563	-0.063	<.001	<.001	3	7
OV	PPP1R18_S224 →	-0.706	-0.048	.005	.001	3	6
OV	ECM1 →	-0.688	-0.054	.002	<.001	3	6
OV	NNMT →	-1.026	-0.056	<.001	.001	3	6
LSCC	PLOD1 →	-0.506	-0.059	<.001	<.001	3	6
LSCC	C1R →	-0.380	-0.061	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009249 vs P4HA2 — OV

Explore this scatter interactively →