Protein lipoylation

Across TCGA cell cohorts, RNA activity of the Protein lipoylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN26, ANK3, and RTN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN26 grouped by Protein lipoylation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZSCAN26 →	-1.197	-0.428	.002	.002	3	5
PANCREAS	ANK3 →	-1.330	-0.184	.005	.001	3	5
LUNG_SCLC	RTN2 →	-1.352	-0.169	.007	.009	3	4
LUNG_SCLC	FAM86B2 →	+0.805	+0.195	.001	.001	3	4
BONE	USP28 →	-0.899	-0.323	.004	<.001	3	3
SKIN	CITED1 →	+2.136	+0.253	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN26 by Protein lipoylation activity — BLOOD_Myeloma

Explore this box plot interactively →