Glycolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VN1R21P, TREM2, and CORO2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid biosynthetic process activity versus VN1R21P in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VN1R21P →	+0.698	+0.221	.002	<.001	3	3
LSCC	TREM2 →	-0.702	-0.232	<.001	.001	3	3
HNSC	CORO2A →	+0.684	+0.201	.001	.001	3	3
GBM	EEA1 →	+0.259	+0.133	.009	.005	3	3
GBM	RPS24 →	-0.313	-0.200	<.001	<.001	3	3
CCRCC	RPL10 →	-0.372	-0.227	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009247 vs VN1R21P — LSCC

Explore this scatter interactively →