Glycolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRIM2, TMEM251, and ALDH16A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRIM2 grouped by Glycolipid biosynthetic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRIM2 →	-1.297	-1.188	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	TMEM251 →	-1.475	-1.412	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ALDH16A1 →	-0.821	-1.431	.002	.001	2	5
UPPER_AERODIGESTIVE_TRACT	SMIM12 →	-1.116	-1.682	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PTMA →	-1.136	-1.427	<.001	.001	3	4
SOFT_TISSUE	FANCL →	+0.971	+1.306	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRIM2 by Glycolipid biosynthetic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →