Glycolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, FAM207A, and MRPS5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid biosynthetic process activity versus IGFBP7 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IGFBP7 →	+2.893	+1.166	<.001	<.001	3	5
SKIN	FAM207A →	-1.128	-1.211	.003	.001	3	5
SKIN	MRPS5 →	-0.750	-1.292	<.001	.001	3	4
BLOOD_Leukemia	USP7 →	-0.939	-1.119	<.001	<.001	3	4
BLOOD_Myeloma	FBXO41 →	-2.050	-1.730	.001	.001	3	4
SKIN	TMEM97 →	-1.467	-1.490	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009247 vs IGFBP7 — BLOOD_Leukemia

Explore this scatter interactively →