Isopentenyl diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Isopentenyl diphosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MVK, MVD, and HMGCS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isopentenyl diphosphate biosynthetic process activity versus MVK in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MVK →	+0.473	+0.052	<.001	<.001	3	9
BRCA	MVD →	+0.377	+0.046	<.001	<.001	3	9
HNSC	HMGCS1 →	+0.739	+0.130	<.001	<.001	3	9
HNSC	IDI1 →	+0.490	+0.197	<.001	.007	3	8
HNSC	MSMO1 →	+0.748	+0.108	<.001	<.001	3	8
LSCC	MMAB →	+0.513	+0.082	.005	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009240 vs MVK — OV

Explore this scatter interactively →