Isopentenyl diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Isopentenyl diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVD, SNORA47, and ACVR2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isopentenyl diphosphate biosynthetic process activity versus MVD in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MVD →	+0.568	+0.211	.007	<.001	2	5
LSCC	SNORA47 →	-0.479	-0.122	<.001	.008	3	4
LUAD	ACVR2B →	-0.272	-0.172	.002	.003	3	4
OV	ZNF785 →	-0.365	-0.076	.007	.003	3	4
LSCC	RPLP1P13 →	-0.371	-0.166	.001	<.001	3	3
PDAC	ST3GAL4 →	+0.531	+0.161	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009240 vs MVD — HNSC

Explore this scatter interactively →