Isopentenyl diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Isopentenyl diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRE11, ZNF236, and ZSCAN30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRE11 grouped by Isopentenyl diphosphate biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRE11 →	-1.176	-1.957	<.001	<.001	3	5
BLOOD_Leukemia	ZNF236 →	-0.914	-1.217	<.001	<.001	3	4
BLOOD_Leukemia	ZSCAN30 →	-0.907	-1.479	<.001	<.001	3	4
CNS	FAHD2A →	+0.544	+0.914	.002	<.001	3	4
URINARY_TRACT	SLC25A12 →	-1.022	-1.791	.006	<.001	3	3
BLOOD_Leukemia	KCNIP2 →	-0.816	-1.059	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRE11 by Isopentenyl diphosphate biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →