Isopentenyl diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Isopentenyl diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3B, TNFRSF12A, and NAXE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isopentenyl diphosphate biosynthetic process activity versus FNDC3B in BONE (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FNDC3B →	-1.857	-1.657	.005	<.001	3	6
LARGE_INTESTINE	TNFRSF12A →	-1.806	-1.097	<.001	.001	3	6
BREAST	NAXE →	+1.025	+1.156	<.001	.005	3	5
BLOOD_Lymphoma	HCN3 →	+0.875	+0.269	<.001	<.001	3	5
BLOOD_Lymphoma	SGMS2 →	-1.404	-0.280	.006	.004	3	5
BLOOD_Lymphoma	GATAD2A →	+0.576	+0.354	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009240 vs FNDC3B — BONE

Explore this scatter interactively →