Cobalamin metabolic process

Across TCGA patient cohorts, RNA activity of the Cobalamin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMAA, CRTAP, and FN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin metabolic process activity versus MMAA in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MMAA →	+0.411	+0.037	<.001	<.001	3	8
GBM	CRTAP →	-0.416	-0.049	.005	<.001	3	7
CCRCC	FN1 →	-0.686	-0.059	<.001	.001	3	7
CCRCC	PLOD1 →	-0.483	-0.068	<.001	<.001	3	7
CCRCC	CD14 →	-0.340	-0.044	<.001	<.001	3	7
CCRCC	C1QC →	-0.747	-0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009235 vs MMAA — COAD

Explore this scatter interactively →