Cobalamin metabolic process

Across TCGA patient cohorts, RNA activity of the Cobalamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNF, BNIP3P11, and MSH6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin metabolic process activity versus CCNF in LUAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCNF →	-0.489	-0.111	<.001	<.001	3	5
OV	BNIP3P11 →	-1.161	-0.138	<.001	.004	3	5
LUAD	MSH6 →	-0.330	-0.130	<.001	.001	3	4
LUAD	FIGNL1 →	-0.587	-0.139	.001	<.001	3	4
HNSC	PHF11 →	+0.459	+0.125	.001	.009	3	4
LUAD	TICRR →	-0.706	-0.137	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009235 vs CCNF — LUAD

Explore this scatter interactively →