Cobalamin metabolic process

Across TCGA cell cohorts, RNA activity of the Cobalamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPA3, MORN1, and ASH1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPA3 grouped by Cobalamin metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OPA3 →	+0.573	+1.188	.002	.003	3	5
BLOOD_Leukemia	MORN1 →	+0.789	+0.920	<.001	.005	3	4
OESOPHAGUS	ASH1L →	+0.748	+1.326	.003	<.001	3	4
PANCREAS	PREPL →	+0.884	+1.242	.001	<.001	3	4
PANCREAS	IMMP1L →	+1.045	+0.992	.007	.004	3	4
OESOPHAGUS	SMG5 →	+0.579	+1.191	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPA3 by Cobalamin metabolic process activity — OESOPHAGUS

Explore this box plot interactively →