Cobalamin metabolic process

Across TCGA cell cohorts, RNA activity of the Cobalamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, PPP1R18, and MAP7D1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin metabolic process activity versus ITGB1 in BONE (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ITGB1 →	-1.924	-0.118	<.001	<.001	3	9
STOMACH	PPP1R18 →	-1.642	-0.093	.005	.006	1	10
LARGE_INTESTINE	MAP7D1 →	-0.973	-0.067	<.001	.002	3	8
BONE	NPC1 →	-1.746	-0.136	<.001	<.001	3	8
BONE	OSTM1 →	-0.923	-0.072	.004	.006	3	8
BONE	SEMA7A →	-2.550	-0.083	<.001	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009235 vs ITGB1 — BONE

Explore this scatter interactively →