Cobalamin metabolic process

Across TCGA cell cohorts, RNA activity of the Cobalamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHACTR3, DCTD, and VSIG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin metabolic process activity versus PHACTR3 in CNS (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PHACTR3 →	+0.067	+1.367	.001	.001	3	4
BLOOD_Lymphoma	DCTD →	-2.147	-0.519	<.001	.001	3	4
SKIN	VSIG1 →	+0.330	+1.616	.003	.004	3	3
BLOOD_Lymphoma	RALGPS2 →	+4.244	+0.902	<.001	.005	3	3
SKIN	EFCAB11 →	+1.113	+1.533	.009	.002	3	3
SKIN	ARRDC4 →	+2.559	+1.948	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009235 vs PHACTR3 — CNS

Explore this scatter interactively →