Nucleotide-sugar biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINF1, GFPT2, and P4HA3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar biosynthetic process activity versus SERPINF1 in OV (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+1.329	+0.196	<.001	<.001	3	8
GBM	GFPT2 →	+1.268	+0.181	<.001	<.001	3	7
OV	P4HA3 →	+1.147	+0.273	<.001	<.001	3	7
BRCA	COLEC12 →	+1.257	+0.194	<.001	<.001	3	7
OV	CTHRC1 →	+2.016	+0.282	<.001	<.001	3	7
GBM	KLF17 →	+0.330	+0.136	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009226 vs SERPINF1 — OV

Explore this scatter interactively →