Nucleotide-sugar biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleotide-sugar biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIMKLB, UQCRB, and L1CAM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar biosynthetic process activity versus RIMKLB in OESOPHAGUS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RIMKLB →	-3.107	-1.363	.001	<.001	3	5
URINARY_TRACT	UQCRB →	+0.784	+1.832	.004	.001	3	5
LARGE_INTESTINE	L1CAM →	-2.508	-1.102	<.001	<.001	3	5
STOMACH	BEND7 →	-2.585	-1.356	.005	.007	3	5
LARGE_INTESTINE	ABL2 →	-0.853	-0.800	.005	.002	3	4
STOMACH	SLC43A1 →	+2.893	+1.635	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009226 vs RIMKLB — OESOPHAGUS

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