Nucleotide-sugar metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF17, EDEM3, and PUS7L, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar metabolic process activity versus DCAF17 in UVM (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DCAF17 →	+1.296	+0.066	<.001	<.001	3	33
UVM	EDEM3 →	+1.625	+0.066	<.001	<.001	3	33
UVM	PUS7L →	+1.071	+0.069	<.001	<.001	3	33
DLBC	ZNF41 →	+1.407	+0.068	<.001	<.001	3	33
UVM	SLC30A7 →	+1.446	+0.062	<.001	<.001	3	33
UCS	SPICE1 →	+1.015	+0.038	<.001	.002	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009225 vs DCAF17 — UVM

Explore this scatter interactively →