Nucleotide-sugar metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, ACTN1, and CYGB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar metabolic process activity versus VIM in BRCA (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VIM →	+0.543	+0.040	<.001	<.001	3	7
OV	ACTN1 →	+0.482	+0.054	<.001	<.001	3	6
OV	CYGB →	+0.792	+0.063	<.001	<.001	3	6
BRCA	MIOS_S766 →	-0.375	-0.033	<.001	<.001	3	6
BRCA	SPARCL1_S198 →	+0.849	+0.035	<.001	<.001	3	5
BRCA	ESF1_S198 →	-0.573	-0.037	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009225 vs VIM — BRCA

Explore this scatter interactively →