Nucleotide-sugar metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleotide-sugar metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADPS2, TOX3, and GORASP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar metabolic process activity versus CADPS2 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CADPS2 →	+1.041	+0.553	.003	.002	3	4
BREAST	TOX3 →	+1.307	+0.535	.009	.009	3	4
BLOOD_Leukemia	GORASP2 →	+0.702	+1.283	<.001	<.001	3	4
BREAST	ZBTB8B →	-0.204	-0.630	.009	.002	3	4
STOMACH	CBX4 →	+1.794	+1.237	.008	.007	2	5
STOMACH	KIF13B →	+1.293	+0.929	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009225 vs CADPS2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →