Pyrimidine deoxyribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMPK2, MX1, and OAS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleotide biosynthetic process activity versus CMPK2 in BRCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMPK2 →	+1.358	+0.188	<.001	<.001	3	7
BRCA	MX1 →	+1.424	+0.171	<.001	.001	3	7
HNSC	OAS3 →	+0.790	+0.135	<.001	<.001	3	6
HNSC	IFIT2 →	+1.571	+0.176	<.001	<.001	3	6
BRCA	IFI44L →	+1.346	+0.183	<.001	<.001	3	6
HNSC	USP18 →	+1.168	+0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009221 vs CMPK2 — BRCA

Explore this scatter interactively →