Pyrimidine deoxyribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACE, MAPK15, and CREB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACE grouped by Pyrimidine deoxyribonucleotide biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACE →	+1.603	+0.285	.005	.004	3	5
LIVER	MAPK15 →	+1.013	+0.184	.008	.007	3	5
LUNG_NSCLC_LUSC	CREB3 →	+1.128	+0.277	.007	.001	3	4
STOMACH	ANP32B →	-0.582	-0.406	.008	.002	3	4
STOMACH	PLCD1 →	+1.069	+0.268	.003	.008	3	4
LUNG_SCLC	ATF5 →	-1.499	-0.134	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACE by Pyrimidine deoxyribonucleotide biosynthetic process activity — STOMACH

Explore this box plot interactively →